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lüll The Gli code: an information nexus regulating cell fate, stemness and cancer Ruiz i Altaba A; Mas C; Stecca BTrends Cell Biol 2007[Sep]; 17 (9): 438-47The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.|*Body Patterning[MESH]|*Neoplasms/metabolism/pathology/physiopathology/therapy[MESH]|Animals[MESH]|Cell Differentiation/physiology[MESH]|Cellular Senescence[MESH]|Disease Progression[MESH]|Gene Expression Regulation, Developmental[MESH]|Hedgehog Proteins/*metabolism[MESH]|Humans[MESH]|Neoplasm Metastasis[MESH]|Oncogene Proteins/genetics/*metabolism[MESH]|Oncogenes[MESH]|Signal Transduction/*physiology[MESH]|Stem Cells/cytology/*physiology[MESH]|Trans-Activators/genetics/*metabolism[MESH]|Zinc Finger Protein GLI1[MESH] |