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lüll PTEN: its deregulation and tumorigenesis Maehama TBiol Pharm Bull 2007[Sep]; 30 (9): 1624-7The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferation of cells, leading to oncogenic transformation. Recent studies have identified a number of upstream regulatory factors for PTEN and unveiled that the impairment in the PTEN regulatory system potentially becomes a causal factor for oncogenic transformation of cells. This article will review the PTEN inactivation mechanism which is linked to human tumorigenesis, particularly focusing on recent research progress in PTEN regulators.|Animals[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Mutation/physiology[MESH]|Neoplasms/*genetics/*physiopathology[MESH]|PTEN Phosphohydrolase/genetics/metabolism/*physiology[MESH]|Phosphoinositide-3 Kinase Inhibitors[MESH] |