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The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4,5P(2) Kanaho Y; Kobayashi-Nakano A; Yokozeki TBiol Pharm Bull 2007[Sep]; 30 (9): 1605-9The phosphoinositide kinase, phosphatidylinositol 4-phosphate 5-kinase (PIP5K), produces the versatile phospholipid phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)), through which PIP5K plays crucial roles in a wide variety of cell functions. So far, three PIP5K isozymes and splicing variants have been identified. We speculate that each PIP5K isozyme or splicing variant is activated in a tempo-spatially different manner, due to the existence of activators or recruiters specific to each isozyme: this tempo-spatially different activation of PIP5K produces PI4,5P(2) at different compartments of the cell at different times, which phenomenon may be responsible for the apparent multifunction of PI4,5P(2)/PIP5K. Accumulating evidence supports this notion that each PIP5K isozyme is activated by its specific activator and plays a crucial role in a unique cell function. In this article, we describe recent advances regarding the PIP5K isozyme-specific activation mechanisms and physiological functions.|Animals[MESH]|Enzyme Activation/physiology[MESH]|Humans[MESH]|Minor Histocompatibility Antigens[MESH]|Phosphatidylinositol 4,5-Diphosphate/*physiology[MESH]|Phosphotransferases (Alcohol Group Acceptor)/*physiology[MESH]|Signal Transduction/*physiology[MESH]|Subcellular Fractions/metabolism[MESH] |
