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Metabolic implications of GH treatment in small for gestational age Delemarre EM; Rotteveel J; Delemarre-van de Waal HAEur J Endocrinol 2007[Aug]; 157 Suppl 1 (ä): S47-50Fetal growth retardation is associated with decreased postnatal growth, resulting in a lower adult height. In addition, a low birth weight is associated with an increased risk of developing diseases during adulthood, such as insulin resistance, type 2 diabetes mellitus, hypertension, dyslipidemia, and cardiovascular diseases. Children with persistent postnatal growth retardation, i.e., incomplete catch-up growth, can be treated with human GH. The GH/IGF-I axis is involved in the regulation of carbohydrate and lipid metabolism. The question of whether treatment with GH in children born small for gestational age (SGA) has long-term implications with respect to glucose/insulin and lipid metabolism has not been answered yet. In this article, the available data are reviewed.|Body Height[MESH]|Glucose/metabolism[MESH]|Growth Disorders/drug therapy[MESH]|Growth Hormone/*therapeutic use[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Infant, Small for Gestational Age/*growth & development/*metabolism[MESH]|Insulin/metabolism[MESH]|Lipid Metabolism[MESH] |
