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lüll Meta-analysis: enteral nutrition in active Crohn s disease in children Dziechciarz P; Horvath A; Shamir R; Szajewska HAliment Pharmacol Ther 2007[Sep]; 26 (6): 795-806BACKGROUND: Controversy exists surrounding the optimal treatment for inducing remission in active Crohn's disease. AIM: To review and update evidence on the effectiveness of enteral nutrition (EN) in treating active Crohn's disease in children. METHODS: MEDLINE, EMBASE and The Cochrane Library (up to February 2007) were searched for randomized controlled trials (RCTs) relevant to Crohn's disease and EN in children. RESULTS: We included 11 RCTs (n = 394). Seven RCTs (n = 204) compared EN with corticosteroid therapy. On the basis of pooled results of four RCTs (n = 144), we found no significant difference in the remission rates between groups (relative risk, RR 0.97, 95% CI 0.7-1.4, random effect model). Four RCTs (n = 190) compared two EN regimens. One of the four RCTs (n = 50) revealed a significant increase in the percentage of patients achieving remission in the total EN group compared with the partial EN group (RR 2.7, 95% CI 1-7.4). Because of lack of data, formal pooling of results was not possible for many outcomes (e.g., time until remission, duration of remission, growth data). CONCLUSIONS: Limited data suggest similar efficacy for EN and corticosteroids. As the number of patients needed to provide a definite answer is too large, future studies should focus on detailed outcome measurements including growth and quality of life.|*Enteral Nutrition[MESH]|Adolescent[MESH]|Adrenal Cortex Hormones/pharmacology/therapeutic use[MESH]|Child[MESH]|Crohn Disease/*therapy[MESH]|Female[MESH]|Gastrointestinal Agents/pharmacology/*therapeutic use[MESH]|Humans[MESH]|Male[MESH]|Quality of Life/psychology[MESH]|Remission Induction/methods[MESH]|Treatment Outcome[MESH] |