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lüll Evaluating the cost-effectiveness of reduced tardive dyskinesia with second-generation antipsychotics Rosenheck RABr J Psychiatry 2007[Sep]; 191 (ä): 238-45BACKGROUND: Second-generation antipsychotics may have few advantages over older, cheaper drugs, except for possibly reduced risk of tardive dyskinesia. AIMS: To evaluate the cost-effectiveness of second-generation antipsychotics with regard to reducing tardive dyskinesia. METHOD: Literature was reviewed on risk of tardive dyskinesia with second-generation antipsychotics; on severity, duration and impairment of tardive dyskinesia; and on the relationship of this disorder to quality of life and quality-adjusted life-years (QALYs). Diverse cost and benefit assumptions and of 1-year and 5-year planning horizons were examined in a deterministic sensitivity analysis. RESULTS: Estimating 0.143 QALYs lost per case of severe tardive dyskinesia, 1-year cost-effectiveness cumulative estimates ranged from pounds 74,000 (dollars 149,000) to pounds 342,000 (dollars 683,000) per QALY, all above the conventional policy threshold of pounds 25,000 (dollars 50,000). CONCLUSIONS: Reduction of tardive dyskinesia with second-generation antipsychotics appears unlikely to meet standards for cost-effectiveness.|Antipsychotic Agents/adverse effects/*economics/therapeutic use[MESH]|Cost-Benefit Analysis[MESH]|Dyskinesia, Drug-Induced/*economics[MESH]|Humans[MESH]|Psychotic Disorders/drug therapy/*economics/psychology[MESH]|Quality of Life/psychology[MESH]|Quality-Adjusted Life Years[MESH] |