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lüll IL-10-producing type 1 regulatory T cells and allergy Wu K; Bi Y; Sun K; Wang CCell Mol Immunol 2007[Aug]; 4 (4): 269-75As an important subset of regulatory T (Treg) cells, IL-10-producing type 1 regulatory T cells (Tr1), have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells). Similar to nTreg cells, Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effector T cells to a Tr1 phenotype appears to be a critical event in successful allergen-specific immunotherapy and glucocorticoids and beta2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-beta. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases.|Animals[MESH]|Humans[MESH]|Hypersensitivity/*immunology[MESH]|Immunotherapy[MESH]|Interleukin-10/*biosynthesis[MESH]|T-Lymphocytes, Regulatory/*immunology/*metabolism[MESH] |