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lüll Radiotherapeutic alternatives for previously irradiated recurrent gliomas Combs SE; Debus J; Schulz-Ertner DBMC Cancer 2007[Aug]; 7 (ä): 167Re-irradiation for recurrent gliomas has been discussed controversially in the past. This was mainly due to only marginal palliation while being associated with a high risk for side effects using conventional radiotherapy. With modern high-precision radiotherapy re-irradiation has become a more wide-spread, effective and well-tolerated treatment option. Besides external beam radiotherapy, a number of invasive and/or intraoperative radiation techniques have been evaluated in patients with recurrent gliomas. The present article is a review on the available methods in radiation oncology and summarizes results with respect to outcome and side effects in comparison to clinical results after neurosurgical resection or different chemotherapeutic approaches.|Antineoplastic Agents/therapeutic use[MESH]|Brachytherapy/adverse effects/methods[MESH]|Brain Neoplasms/*radiotherapy/surgery/therapy[MESH]|Clinical Trials as Topic[MESH]|Combined Modality Therapy[MESH]|Cranial Irradiation/adverse effects/*methods[MESH]|Disease Progression[MESH]|Disease-Free Survival[MESH]|Dose Fractionation, Radiation[MESH]|Glioma/*radiotherapy/surgery/therapy[MESH]|Humans[MESH]|Hyperthermia, Induced[MESH]|Neoplasm Recurrence, Local/*radiotherapy/therapy[MESH]|Palliative Care/methods[MESH]|Prognosis[MESH]|Radiosurgery/adverse effects/methods[MESH]|Radiotherapy, Conformal/adverse effects/methods[MESH]|Radiotherapy, Intensity-Modulated/adverse effects/methods[MESH]|Salvage Therapy/*methods[MESH]|Treatment Outcome[MESH] |