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lüll Neuropsychiatric manifestations in CADASIL Chabriat H; Bousser MGDialogues Clin Neurosci 2007[]; 9 (2): 199-208Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-artery disease of mid-adulthood caused by mutations of the NOTCH3 gene. The disease is responsible for widespread white-matter lesions associated with lacunar infarctions in various subcortical areas. The disease is responsible for migraine with aura and ischemic strokes, and is associated with various degrees of cognitive impairment and with mood disturbances. CADASIL is considered as a unique model to investigate what is known as "subcortical ischemic vascular dementia." Recent data suggest that the number of lacunar infarctions and severity of cerebral atrophy are the main magnetic resonance imaging markers associated with cognitive and motor disabilities in this disorder. Mood disturbances are reported in 10% to 20% of patients, most often in association with cognitive alterations. Their exact origin remains unknown; the presence of ischemic lesions within the basal ganglia or the frontal white matter may promote the occurrence of these symptoms. Further studies are needed to better understand the relationships between cerebral lesions and both cognitive and psychiatric symptoms in this small-vessel disease of the brain.|Brain Infarction/etiology/pathology/physiopathology[MESH]|Brain/*pathology/*physiopathology[MESH]|CADASIL/*complications/*psychology[MESH]|Cerebral Arteries/pathology/physiopathology[MESH]|Cognition Disorders/etiology/physiopathology[MESH]|Diagnosis, Differential[MESH]|Disease Progression[MESH]|Humans[MESH]|Mood Disorders/etiology/physiopathology[MESH]|Neurocognitive Disorders/*etiology/*physiopathology[MESH] |