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The molecular underpinnings of genetic phenomena Lehman NHeredity (Edinb) 2008[Jan]; 100 (1): 6-12Epiphenomena are those processes that ostensibly have no precedent at lower levels of scientific organization. In this review, it is argued that many genetic processes, including ploidy, dominance, heritability, pleiotropy, epistasis, mutational load and recombination, all are at least analogous to biochemical events that were requisite features of the RNA world. Most, if not all, of these features of contemporary whole organisms and populations may have their ultimate evolutionary roots in the chemical repertoire of catalytic RNAs. Some of these phenomena will eventually prove to be not only analogous but homologous to ribozyme activities.|*Evolution, Molecular[MESH]|Animals[MESH]|Epistasis, Genetic[MESH]|Genes, Dominant[MESH]|Genetic Load[MESH]|Genetic Variation[MESH]|Mutation[MESH]|Ploidies[MESH]|Quantitative Trait, Heritable[MESH]|RNA/*genetics[MESH]|Recombination, Genetic[MESH] |
