Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Recklessness as a hallmark of aggressive cancer Noda M; Takahashi CCancer Sci 2007[Nov]; 98 (11): 1659-65Cancer recurrence after surgical treatment is a major concern for patients and doctors. Understanding what makes tumors prone to recurrence would be an important step toward its prevention. Accumulating evidence indicates that the level of membrane-associated protease regulator reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expressed in tumor tissue is a good prognostic indicator in several common cancers. Certain members of the matrix metalloproteinase family are often upregulated in advanced cancers and are known to play important roles in tumor angiogenesis, invasion and metastasis. RECK negatively regulates several matrix metalloproteinases. Therefore, RECK itself may well be considered a promising tool or target molecule to be activated in cancer therapy. Here we review the recent advances in RECK research and discuss some of the important issues to be addressed in future studies.|Biomarkers, Tumor[MESH]|Breast Neoplasms/pathology[MESH]|Carcinoma, Hepatocellular/pathology[MESH]|Colorectal Neoplasms/pathology[MESH]|Female[MESH]|GPI-Linked Proteins[MESH]|Humans[MESH]|Liver Neoplasms/pathology[MESH]|Lung Neoplasms/pathology[MESH]|Male[MESH]|Matrix Metalloproteinases/physiology[MESH]|Membrane Glycoproteins/physiology[MESH]|Neoplasm Recurrence, Local[MESH]|Neoplasms/*genetics/*pathology/surgery[MESH]|Pancreatic Neoplasms/pathology[MESH]|Prostatic Neoplasms/pathology[MESH] |