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lüll Aurora-A: the maker and breaker of spindle poles Barr AR; Gergely FJ Cell Sci 2007[Sep]; 120 (Pt 17): 2987-96The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although Aurora-A may not be a bona fide oncoprotein in humans, it is a promising drug target in cancer therapy. Thus, it is surprising that so little is known of its role in normal cells. The primary function of Aurora-A is to promote bipolar spindle assembly, but the molecular details of this process remained obscure until recently. The discovery of several novel Aurora-A-binding proteins and substrates has implicated Aurora-A in centrosome maturation and separation, acentrosomal and centrosomal spindle assembly, kinetochore function, cytokinesis and in cell fate determination. Here we discuss recent advances in determining the early mitotic role of Aurora-A, with a strong emphasis on its function at the mitotic spindle poles.|*Mitosis[MESH]|Animals[MESH]|Aurora Kinases[MESH]|Cell Cycle Proteins/genetics/metabolism[MESH]|Centrosome/metabolism[MESH]|Humans[MESH]|Phenotype[MESH]|Protein Serine-Threonine Kinases/genetics/*metabolism[MESH]|Spindle Apparatus/*metabolism[MESH] |