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lüll Alveolar epithelial beta2-adrenergic receptors Mutlu GM; Factor PAm J Respir Cell Mol Biol 2008[Feb]; 38 (2): 127-34beta(2)-adrenergic receptors are present throughout the lung, including the alveolar airspace, where they play an important role for regulation of the active Na(+) transport needed for clearance of excess fluid out of alveolar airspace. beta(2)-adrenergic receptor signaling is required for up-regulation of alveolar epithelial active ion transport in the setting of excess alveolar edema. The positive, protective effects of beta(2)-adrenergic receptor signaling on alveolar active Na(+) transport in normal and injured lungs provide substantial support for the use of beta-adrenergic agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with emphasis on their role in the regulation of alveolar active Na(+) transport in normal and injured lungs.|Adrenergic beta-2 Receptor Agonists[MESH]|Adrenergic beta-Agonists/therapeutic use[MESH]|Animals[MESH]|Humans[MESH]|Protein Conformation[MESH]|Pulmonary Alveoli/*metabolism[MESH]|Pulmonary Edema/drug therapy[MESH]|Receptors, Adrenergic, beta-2/chemistry/*metabolism[MESH]|Signal Transduction[MESH] |