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MALT lymphoma involving the kidney: a report of 10 cases and review of the literature Garcia M; Konoplev S; Morosan C; Abruzzo LV; Bueso-Ramos CE; Medeiros LJAm J Clin Pathol 2007[Sep]; 128 (3): 464-73Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) can arise at any anatomic site, but involvement of the kidney is rare. We describe 10 cases of kidney MALT lymphoma, including 6 localized cases. No predisposing inflammatory conditions were identified, with the possible exception of coexistent renal Actinomyces infection in 1 case. We performed fluorescence in situ hybridization (FISH) using a malt1 break-apart probe in 7 cases. A malt1 gene rearrangement was identified in 1 case (14%). This case was further assessed by FISH using an IgH breakapart probe that showed IgH gene rearrangement. These results are suggestive of the t(14;18) involving malt1 and IgH. Immunostaining for NF-kappaB p65 showed nuclear positivity, consistent with NF-kappaB activation, in 3 of 5 cases assessed. Our results indicate that kidney MALT lymphomas share similarities with MALT lymphomas arising at other sites in that MALT lymphoma-associated translocations and NF-kappaB activation occur in a subset of cases.|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Caspases/*metabolism[MESH]|Enzyme Activation[MESH]|Female[MESH]|Gene Rearrangement[MESH]|Genes, Immunoglobulin Heavy Chain[MESH]|Humans[MESH]|In Situ Hybridization, Fluorescence[MESH]|Kidney Neoplasms/*genetics/*metabolism/pathology[MESH]|Lymphoma, B-Cell, Marginal Zone/*genetics/*metabolism/pathology[MESH]|Male[MESH]|Middle Aged[MESH]|Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein[MESH]|NF-kappa B/biosynthesis[MESH]|Neoplasm Proteins/*metabolism[MESH]|Translocation, Genetic[MESH] |
