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High-frequency ultrasound characteristics of 24 iris and iridociliary melanomas: before and after plaque brachytherapy Finger PT; Reddy S; Chin KArch Ophthalmol 2007[Aug]; 125 (8): 1051-8OBJECTIVE: To evaluate size, characteristics, and regression of iris and iridociliary melanomas on high-frequency ultrasound images before and after plaque brachytherapy. METHODS: Retrospective review of high-frequency ultrasound characteristics of 24 consecutive iris and iridociliary melanomas before and after radiation therapy. RESULTS: The median tumor thickness before radiation therapy was 2.3 mm (range, 1.4-4.3 mm). Nineteen iris melanomas (79%) involved the ciliary body, 18 (75%) involved the iris pigment epithelium, 11 (46%) were club shaped, and 4 (17%) caused disinsertion of the iris root. At a median follow-up of 30 months after plaque brachytherapy, the mean tumor thickness had diminished to 1.2 mm (median, 1.2 mm; range, 0.9-1.9 mm). While all tumors exhibited a reduction in thickness, no tumors showed additional regression after 30 months past treatment. Fourteen tumors (58%) were noted to have increases in internal reflectivity. There was 1 failure of local control (at 6 years), successfully treated by a second application of plaque brachytherapy. CONCLUSION: High-frequency ultrasonography revealed unique tumor characteristics, quantified tumor size, and demonstrated tumor response to radiation therapy.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Brachytherapy[MESH]|Ciliary Body/*diagnostic imaging[MESH]|Disease Progression[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Humans[MESH]|Iris Neoplasms/*diagnostic imaging/radiotherapy[MESH]|Male[MESH]|Melanoma/*diagnostic imaging/radiotherapy[MESH]|Middle Aged[MESH]|Prognosis[MESH]|Retrospective Studies[MESH]|Time Factors[MESH]|Ultrasonography[MESH]|Uveal Neoplasms/diagnostic imaging[MESH] |
