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lüll Meta-analysis: The utility and safety of heparin in the treatment of active ulcerative colitis Shen J; Ran ZH; Tong JL; Xiao SDAliment Pharmacol Ther 2007[Sep]; 26 (5): 653-63BACKGROUND: The use of heparin for the treatment of ulcerative colitis has been evaluated in several open and controlled trials, with varying outcomes. AIM: To evaluate the efficacy and safety of heparin as supplemental therapy compared with conventional therapy in patients with ulcerative colitis. METHODS: All randomized trials comparing heparin supplementation to conventional therapy were included from electronic databases. Statistical analysis was performed with review manager 4.2.8 (The Cochrane Collaboration, Oxford, UK). Sub-analysis and sensitivity analysis were also performed. RESULTS: Eight randomized-controlled trials, investigating a total of 454 participants, met the inclusion criteria. The odds ratio (OR) for the efficacy of heparin supplementation vs. conventional therapy was 0.78 (95% CI = 0.50-1.21). Few serious adverse events were observed. The OR for the efficacy of unfractionated heparin and low-molecular-weight heparin vs. conventional therapy was 0.26 (95% CI = 0.07-0.93) and 0.92 (95% CI = 0.57-1.47), respectively. The OR for the efficacy of heparin vs. conventional therapy with placebo was 0.87 (95% CI = 0.53-1.44). CONCLUSIONS: Our meta-analysis suggests that administration of heparin in patients with ulcerative colitis is safe, but no additive benefit over conventional therapy is indicated.|Analysis of Variance[MESH]|Anticoagulants/administration & dosage/*adverse effects[MESH]|Colitis, Ulcerative/*drug therapy[MESH]|Drug Therapy, Combination[MESH]|Female[MESH]|Heparin/administration & dosage/*adverse effects[MESH]|Humans[MESH]|Male[MESH]|Odds Ratio[MESH]|Randomized Controlled Trials as Topic[MESH]|Sensitivity and Specificity[MESH]|Treatment Outcome[MESH] |