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lüll Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family Csortos C; Kolosova I; Verin ADAm J Physiol Lung Cell Mol Physiol 2007[Oct]; 293 (4): L843-54Reversible phosphorylation of cytoskeletal and cytoskeleton-associated proteins is a significant element of endothelial barrier function regulation. Therefore, understanding the mechanisms of phosphorylation/dephosphorylation of endothelial cell cytoskeletal proteins is vital to the treatment of severe lung disorders such as high permeability pulmonary edema. In vivo, there is a controlled balance between the activities of protein kinases and phosphatases. Due to various external or internal signals, this balance may be shifted. The actual balances at a given time alter the phosphorylation level of certain proteins with appropriate physiological consequences. The latest information about the structure and regulation of different types of Ser/Thr protein phosphatases participating in the regulation of endothelial cytoskeletal organization and barrier function will be reviewed here.|Animals[MESH]|Capillary Permeability/*physiology[MESH]|Cytoskeleton/*physiology/*ultrastructure[MESH]|Endothelial Cells/*metabolism/*ultrastructure[MESH]|Humans[MESH]|Phosphoprotein Phosphatases/*physiology[MESH] |