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lüll Inhibitory costimulation and anti-tumor immunity Martin-Orozco N; Dong CSemin Cancer Biol 2007[Aug]; 17 (4): 288-98Costimulation was originally shown to be important in T-cell activation and effector differentiation. Recent characterization of B7/butyrophilin and members of the CD28 superfamily has revealed a large number of negative costimulatory molecules that dampen T-cell activation and regulate immune tolerance. Some of these molecules have been shown to be upregulated in the tumor microenvironment and may serve as potential targets for augmenting anti-tumor immunity. In this article, we summarize recent developments in the field of inhibitory costimulation and discuss the future direction of therapeutic manipulation of inhibitory costimulation in tumor immunotherapy.|Animals[MESH]|B7-1 Antigen/*immunology[MESH]|B7-2 Antigen/*immunology[MESH]|Butyrophilins[MESH]|Humans[MESH]|Immunity[MESH]|Lymphocyte Activation[MESH]|Membrane Glycoproteins/immunology[MESH]|Neoplasms/*immunology/therapy[MESH]|T-Lymphocytes, Cytotoxic/immunology[MESH] |