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The role of dendritic cells in the immunopathogenesis of psoriasis Jariwala SPArch Dermatol Res 2007[Oct]; 299 (8): 359-66Psoriasis vulgaris is a chronic inflammatory skin disease that is marked by a complex interplay of dendritic cells (DCs), T-cells, cytokines, and downstream transcription factors as part of a self-sustaining type 1 cytokine network. As integral players of the immune system, DCs represent antigen-presenting cells that are crucial for efficient activation of T-cells and B-cells. DCs have also been linked to distinct chronic inflammatory conditions, including psoriasis. In the setting of psoriasis therapy, DC/T cell interactions serve as a potential target for biologic response modifiers. Here we describe the major DC subsets as well as the immunologic involvement of DCs within the context of psoriatic lesions.|Cell Communication/immunology[MESH]|Humans[MESH]|Langerhans Cells/*immunology/*pathology[MESH]|Psoriasis/*immunology/*pathology[MESH]|T-Lymphocytes/immunology/pathology[MESH] |
