Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Identifying Atg1 substrates: four means to an end Deminoff SJ; Herman PKAutophagy 2007[Nov]; 3 (6): 667-73Autophagy is essential for normal development and the response to a variety of stress conditions, including nutrient deprivation. The Atg1 serine/threonine-specific protein kinase appears to be a key regulator of many forms of autophagy that occur in eukaryotic cells. Therefore, to fully understand the regulation of autophagy, it is essential that we identify the signaling pathways regulating Atg1 and the physiologically-relevant targets of Atg1 kinase activity. Although some progress has been made on the former question, no Atg1 substrates important for autophagy have yet been identified. In this review, we discuss four different experimental strategies that should facilitate the search for Atg1 substrates.|*Evolution, Molecular[MESH]|Animals[MESH]|Autophagy/*physiology[MESH]|Cyclic AMP-Dependent Protein Kinases/metabolism/physiology[MESH]|Eukaryotic Cells/physiology[MESH]|Humans[MESH]|Models, Biological[MESH]|Protein Serine-Threonine Kinases/metabolism/*physiology[MESH]|Proteomics[MESH]|Signal Transduction[MESH]|Substrate Specificity[MESH] |