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lüll Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer Hecht JR; Patnaik A; Berlin J; Venook A; Malik I; Tchekmedyian S; Navale L; Amado RG; Meropol NJ Cancer 2007[Sep]; 110 (5): 980-8 BACKGROUND: The safety and efficacy of the fully human antibody panitumumab was evaluated in patients with metastatic colorectal cancer refractory to available therapies. METHODS: This phase 2 open-label, multicenter study of panitumumab enrolled patients with metastatic colorectal cancer who had progressed on chemotherapy that included a fluoropyrimidine and irinotecan or oxaliplatin, or both. All patients had tumors with > or =10% 1+ epidermal growth factor receptor (EGFr) staining by immunohistochemistry. Patients were stratified into 2 strata (high or low staining intensity) and received intravenous panitumumab 2.5 mg/kg weekly 8 of every 9 weeks until disease progression or unacceptable toxicity. RESULTS: In all, 148 patients received panitumumab, 105 in the high EGFr stratum, 43 in the low EGFr stratum. Overall response by central review was 9% (95% confidence interval [CI], 5%-15%) and was similar between strata. An additional 29% of patients had stable disease. Median progression-free survival was 14 weeks (95% CI, 8-16) and median overall survival was 9 months (95% CI, 6-10). Toxicities were manageable, with skin toxicity reported in 95% of patients (5% grade 3 or 4). Four patients discontinued therapy because of toxicity. No antipanitumumab antibodies were detected. One patient had an infusion reaction but was able to continue therapy. CONCLUSIONS: Panitumumab given weekly was well tolerated and had single-agent activity in previously treated patients with colorectal cancer. Dermatologic toxicity was common but rarely severe. Ongoing studies will determine panitumumab activity earlier in the course of treatment for colorectal cancer and in combination with other antineoplastic agents. |Adenocarcinoma/*drug therapy/metabolism/pathology[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Monoclonal/administration & dosage/pharmacokinetics/*therapeutic use[MESH] |Antineoplastic Agents/administration & dosage/adverse effects/therapeutic use[MESH] |Camptothecin/analogs & derivatives/therapeutic use[MESH] |Colorectal Neoplasms/*drug therapy/metabolism/pathology[MESH] |Diarrhea/chemically induced[MESH] |Drug Administration Schedule[MESH] |ErbB Receptors/analysis/immunology[MESH] |Fatigue/chemically induced[MESH] |Female[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |Infusions, Intravenous[MESH] |Irinotecan[MESH] |Male[MESH] |Middle Aged[MESH] |Nausea/chemically induced[MESH] |Neoplasm Metastasis[MESH] |Organoplatinum Compounds/therapeutic use[MESH] |Oxaliplatin[MESH] |Panitumumab[MESH] |Skin Diseases/chemically induced[MESH] |Survival Analysis[MESH] |Time Factors[MESH] |Treatment Outcome[MESH]

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*<b>[http://www.kidney.de/mlpefetch.php?search=17671985 Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer ]</b> Cancer 2007; 110(5) ; 980-8 Hecht JR; Patnaik A; Berlin J; Venook A; Malik I; Tchekmedyian S; Navale L; Amado RG; Meropol NJ

    *17671985*

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{{recpmid|pmid=17671985|ti=Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer |au=Hecht JR; Patnaik A; Berlin J; Venook A; Malik I; Tchekmedyian S; Navale L; Amado RG; Meropol NJ|so=Cancer 2007; 110 (5): 980-8|ab=BACKGROUND: The safety and efficacy of the fully human antibody panitumumab was evaluated in patients with metastatic colorectal cancer refractory to available therapies. METHODS: This phase 2 open-label, multicenter study of panitumumab enrolled patients with metastatic colorectal cancer who had progressed on chemotherapy that included a fluoropyrimidine and irinotecan or oxaliplatin, or both. All patients had tumors with > or =10% 1+ epidermal growth factor receptor (EGFr) staining by immunohistochemistry. Patients were stratified into 2 strata (high or low staining intensity) and received intravenous panitumumab 2.5 mg/kg weekly 8 of every 9 weeks until disease progression or unacceptable toxicity. RESULTS: In all, 148 patients received panitumumab, 105 in the high EGFr stratum, 43 in the low EGFr stratum. Overall response by central review was 9% (95% confidence interval [CI], 5%-15%) and was similar between strata. An additional 29% of patients had stable disease. Median progression-free survival was 14 weeks (95% CI, 8-16) and median overall survival was 9 months (95% CI, 6-10). Toxicities were manageable, with skin toxicity reported in 95% of patients (5% grade 3 or 4). Four patients discontinued therapy because of toxicity. No antipanitumumab antibodies were detected. One patient had an infusion reaction but was able to continue therapy. CONCLUSIONS: Panitumumab given weekly was well tolerated and had single-agent activity in previously treated patients with colorectal cancer. Dermatologic toxicity was common but rarely severe. Ongoing studies will determine panitumumab activity earlier in the course of treatment for colorectal cancer and in combination with other antineoplastic agents.}}
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{{BibRecord | Autor = Hecht JR; Patnaik A; Berlin J; Venook A; Malik I; Tchekmedyian S; Navale L; Amado RG; Meropol NJ | Titel = Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer | Band = 110 | Nummer = 5 | Jahr = 2007 | Monat = Sep | Sprache = eng | DOI = | Seite = 980-8 | PMID = 17671985 | Typ= {{{Typ|}}} | Kommentar = {{{Kommentar|}}} | format = {{{format|}}} | record = {{{record|}}} }}

Cancer