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Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications Calin GA; Croce CMJ Clin Invest 2007[Aug]; 117 (8): 2059-66There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.|*Chromosome Aberrations[MESH]|*Quantitative Trait Loci[MESH]|Animals[MESH]|Diagnosis, Differential[MESH]|Gene Expression Regulation, Neoplastic/*genetics[MESH]|Humans[MESH]|MicroRNAs/biosynthesis/*genetics[MESH]|Neoplasms/diagnosis/*genetics/metabolism[MESH]|Prognosis[MESH] |
