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  • HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy
  • Dey A; Chao SH; Lane DP
  • Cell Cycle 2007[Aug]; 6 (15): 1856-63
  • Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) is an inhibitor of positive transcription elongation factor b (P-TEFb) that has recently been shown to be involved in cancers, AIDS, cardiac hypertrophy and inflammation. It was first cloned from vascular smooth muscle cells (VSMCs) treated with hexamethylene bis-acetamide (HMBA), a compound that suppresses the proliferation of VSMCs. Little was kappanown about the biological function of HEXIM1 till the discovery of its association with P-TEFb. P-TEFb, a protein complex composed of cyclin-dependent kinase 9 and a cyclin partner, plays a key role in regulation of RNA polymerase II elongation. When associated with 7SK small nuclear RNA, HEXIM1 binds to P-TEFb and inhibits the kinase activity of P-TEFb. This finding provides the molecular basis for the inhibitory function of HEXIM1 in P-TEFb-dependent transcription, such as human immunodeficiency virus Tat transactivation and NFkappaB-mediated transcription. Recent evidences suggest an essential role of HEXIM1 in several diseases through transcriptional regulation.
  • |Acquired Immunodeficiency Syndrome/genetics/*metabolism[MESH]
  • |Animals[MESH]
  • |Cardiomegaly/*metabolism[MESH]
  • |Humans[MESH]
  • |Inflammation/genetics/*metabolism[MESH]
  • |Neoplasms/*metabolism[MESH]
  • |RNA-Binding Proteins/antagonists & inhibitors/*metabolism[MESH]
  • |Transcriptional Elongation Factors/antagonists & inhibitors/*metabolism[MESH]





  • *{{pmid17671421}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=17671421 HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy ]</b> Cell Cycle 2007; 6(15) ; 1856-63 Dey A; Chao SH; Lane DP

        *17671421*

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    Cell Cycle

    1856 15.6 2007