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lüll Molecular pathways for cancer angioprevention Albini A; Noonan DM; Ferrari NClin Cancer Res 2007[Aug]; 13 (15 Pt 1): 4320-5By analogy to the success of cardiovascular medicine in reducing mortality through preventive measures, cancer chemoprevention has the potential to significantly reduce incidence and mortality due to tumors. Angiogenesis is an event inhibited by most of the promising cancer chemoprevention compounds, a concept we termed "angioprevention." Here, we review the signaling pathways that are targeted by diverse angioprevention compounds in endothelial cells. We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice.|*Signal Transduction[MESH]|Angiogenesis Inhibitors/*therapeutic use[MESH]|Animals[MESH]|Humans[MESH]|Neoplasms/*blood supply[MESH]|Neovascularization, Pathologic/*prevention & control[MESH] |