Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17668426&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Targeting vasculature in urologic tumors: mechanistic and therapeutic significance Sakamoto S; Ryan AJ; Kyprianou NJ Cell Biochem 2008[Feb]; 103 (3): 691-708Recent advances toward understanding the molecular mechanisms regulating cancer initiation and progression provide new insights into the therapeutic value of targeting tumor vascularity by interfering with angiogenic signaling pathways. The functional contribution of key angiogenic factors toward increased vascularity characterizing metastatic tumors and their therapeutic exploitation is considered in three major urologic malignancies, renal, bladder, and prostate cancer. With the realization that the success of the therapeutic efficacy of the various anti-angiogenic approaches for the treatment of urologic tumors has yet to be proven clinically, the challenge remains to select critical angiogenesis pathways that can be targeted for an individual tumor. Here we discuss the major mechanisms that support formation of vasculature in renal, bladder, and prostate tumors and the current results of targeting of specific molecules/regulators for therapeutic intervention against metastastic disease.|Angiogenesis Inducing Agents/*antagonists & inhibitors/metabolism[MESH]|Angiogenesis Inhibitors/metabolism/*pharmacology[MESH]|Apoptosis[MESH]|Cell Movement/drug effects[MESH]|Female[MESH]|Humans[MESH]|Immunotherapy/methods[MESH]|Kidney Neoplasms/blood supply[MESH]|Male[MESH]|Neovascularization, Pathologic/*drug therapy/*metabolism/prevention & control[MESH]|Prostatic Neoplasms/blood supply[MESH]|Signal Transduction/*drug effects[MESH]|Urinary Bladder Neoplasms/blood supply[MESH]|Urologic Neoplasms/*blood supply[MESH]|Vascular Endothelial Growth Factor A/metabolism[MESH] |
