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Pharmacological and chemical effects of cigarette additives Rabinoff M; Caskey N; Rissling A; Park CAm J Public Health 2007[Nov]; 97 (11): 1981-91We investigated tobacco industry documents and other sources for evidence of possible pharmacological and chemical effects of tobacco additives. Our findings indicated that more than 100 of 599 documented cigarette additives have pharmacological actions that camouflage the odor of environmental tobacco smoke emitted from cigarettes, enhance or maintain nicotine delivery, could increase the addictiveness of cigarettes, and mask symptoms and illnesses associated with smoking behaviors. Whether such uses were specifically intended for these agents is unknown. Our results provide a clear rationale for regulatory control of tobacco additives.|*Behavior, Addictive/physiopathology[MESH]|*Brain/drug effects/physiopathology[MESH]|*Nicotine/adverse effects/metabolism[MESH]|*Smoking/adverse effects/epidemiology[MESH]|*Tobacco Industry[MESH]|Ammonia/adverse effects/analysis[MESH]|Animals[MESH]|Cognition/drug effects[MESH]|Drug Synergism[MESH]|Electroencephalography[MESH]|Evoked Potentials[MESH]|Humans[MESH]|Nicotinic Agonists/adverse effects/analysis[MESH]|Tobacco Products[MESH]|Tobacco Smoke Pollution/analysis[MESH]|United States/epidemiology[MESH] |
