Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17659805&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Delivery of drugs and macromolecules to mitochondria Mukhopadhyay A; Weiner HAdv Drug Deliv Rev 2007[Aug]; 59 (8): 729-38Mitochondria is where the bulk of the cell's ATP is produced. Mutations occur to genes coding for members of the complexes involved in energy production. Some are a result of damages to nuclear coded genes and others to mitochondrial coded genes. This review describes approaches to bring small molecules, proteins and RNA/DNA into mitochondria. The purpose is to repair damaged genes as well as to interrupt mitochondrial function including energy production, oxygen radical formation and the apoptotic pathway.|Antioxidants/pharmacology[MESH]|Apoptosis/drug effects/physiology[MESH]|Carrier Proteins/metabolism[MESH]|DNA Repair/drug effects/genetics[MESH]|DNA, Mitochondrial/drug effects/genetics[MESH]|Drug Delivery Systems/*methods[MESH]|Humans[MESH]|Macromolecular Substances/*administration & dosage/metabolism[MESH]|Mitochondria/*metabolism[MESH]|Mitochondrial Diseases/drug therapy/metabolism[MESH]|Mitochondrial Membrane Transport Proteins/*metabolism[MESH]|Mitochondrial Membranes/metabolism[MESH]|Mitochondrial Precursor Protein Import Complex Proteins[MESH]|Onium Compounds/metabolism[MESH]|Oxidative Stress[MESH]|Peptide Nucleic Acids/metabolism/*pharmacokinetics[MESH]|Protein Sorting Signals/genetics[MESH]|Reactive Oxygen Species/metabolism[MESH]|Saccharomyces cerevisiae[MESH]|Triphenylmethyl Compounds/metabolism[MESH] |
