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lüll Yttrium 90 microsphere selective internal radiation treatment of hepatic colorectal metastases Gulec SA; Fong YArch Surg 2007[Jul]; 142 (7): 675-82OBJECTIVE: To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases. DATA SOURCES: Published studies and scientific paper presentations. STUDY SELECTION: Randomized clinical studies and retrospective reviews. CONCLUSIONS: Selective internal radiation treatment is a promising new modality in the treatment of patients with hepatic colorectal cancer metastases as part of a multimodality approach. A chemo-selective internal radiation treatment neoadjuvant approach has a potential to improve therapeutic outcomes. Clinical studies in neoadjuvant and salvage settings are needed for more concrete outcome data and design of optimal multimodality treatment strategies.|Brachytherapy/*methods[MESH]|Colonic Neoplasms/*pathology[MESH]|Humans[MESH]|Liver Neoplasms/radiotherapy/*secondary[MESH]|Microspheres[MESH]|Neoadjuvant Therapy[MESH]|Radiopharmaceuticals/*therapeutic use[MESH]|Randomized Controlled Trials as Topic[MESH]|Rectal Neoplasms/*pathology[MESH]|Retrospective Studies[MESH]|Treatment Outcome[MESH]|Yttrium Radioisotopes/*therapeutic use[MESH] |