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Dysautonomia, fibromyalgia and reflex dystrophy Eisinger JArthritis Res Ther 2007[]; 9 (4): 105Autonomic nervous system dysfunction observed in fibromyalgia, characterized without exception by a sympathetic hyperactivity and hyporeactivity, has been reported. However, several studies demonstrated reduced levels of norepinephrine and neuropeptide Y at rest and after tilt table in some patients, which was improved by beta-stimulating agents. These findings support heterogeneity in fibromyalgia-associated dysautonomia. Fibromyalgia could be a generalized sympathetic dystrophy since both conditions are activated by trauma and partly linked to sympathetic mechanisms. Yet they differ on several points: hormonal and neurochemical abnormalities are observed in fibromyalgia whereas activation by peripheral trauma and hyperosteolysis are observed in reflex sympathetic dystrophy.|Autonomic Nervous System Diseases/blood/*physiopathology[MESH]|Fibromyalgia/blood/*physiopathology[MESH]|Humans[MESH]|Neuropeptide Y/blood[MESH]|Norepinephrine/blood[MESH]|Reflex Sympathetic Dystrophy/blood/*physiopathology[MESH]|Tilt-Table Test[MESH] |
