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  • MicroRNA gene expression in malignant lymphoproliferative disorders
  • Xu W; Li JY
  • Chin Med J (Engl) 2007[Jun]; 120 (11): 996-9
  • OBJECTIVE: To review the recent studies about microRNAs and advances in malignant lymphoproliferative disorders. DATA SOURCES: Published articles (2001 - 2006) about microRNAs and malignant lymphoproliferative disorders were selected using MEDLINE. STUDY SELECTION: After independent review by two observers, 43 of 421 originally identified articles were selected that specifically addressed the stated purpose. RESULTS: Two observers independently assessed studies using explicit methodological criteria for evaluating microRNAs in malignant lymphoproliferative disorders. Recent work has revealed a class of small noncoding RNA species, microRNAs, which affect various biological processes. MicroRNAs inhibit the expression of protein encoding genes at the posttranscriptional level in a variety of eukaryotic organisms. In this review, we focused on the biogenetic pathways of microRNAs (miR-15a, miR-16-1, miR-155, miR-17-92 cluster, miR-142) and discussed the implications for human malignant lymphoproliferative disorders. CONCLUSIONS: microRNAs are involved in tumorigenesis and mediate gene regulation as a fundamental genetic program at the posttranscriptional level. Further study of microRNAs may lead to novel concepts in the diagnosis and treatment of malignant lymphoproliferative disorders.
  • |Gene Expression Regulation, Neoplastic[MESH]
  • |Genes, myc[MESH]
  • |Humans[MESH]
  • |Leukemia, Lymphocytic, Chronic, B-Cell/genetics[MESH]
  • |Lymphoproliferative Disorders/diagnosis/*genetics/therapy[MESH]
  • |MicroRNAs/analysis/*physiology[MESH]

  • *{{pmid17624268}}
    *<b>[ MicroRNA gene expression in malignant lymphoproliferative disorders ]</b> Chin Med J (Engl) 2007; 120(11) ; 996-9 Xu W; Li JY


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    Chin Med J (Engl)

    996 11.120 2007