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Real-world utilization patterns of cyclosporine ophthalmic emulsion 0 05% within managed care Chiang TH; Walt JG; McMahon JP Jr; Mansfield JE Jr; Simonyi SCan J Clin Pharmacol 2007[Sum]; 14 (2): e240-5BACKGROUND: Cyclosporine 0.05% ophthalmic emulsion (Restasis) is a treatment for dry eye disease. OBJECTIVES: To examine patients' cyclosporine 0.05% utilization patterns by analyzing prescription fill data. METHODS: A retrospective analysis with a large de-identified longitudinal patient database was conducted. Participants in the study had 1 prescription fill for cyclosporine 0.05% during a 3-month "enrollment" period from January 1 to March 31, 2004, and at least 1 refill within the following 12 months. Continuing patients had at least 1 cyclosporine 0.05% prescription fill, and new patients had none during 12 months prior to the "enrollment" period. Daily, monthly, and annual utilizations were assessed. RESULTS: 38,164 patients met the inclusion criteria. The majority of patients were female (82%), 50 years or older (77%), and new to therapy (59%). The FDA-recommended use is 2 vials daily (2 trays/month, each tray containing 32 vials) to receive the prescribed dosage of 1 drop in each eye twice daily. Prescription refill patterns demonstrated 73% of patients used 1 tray/month; similarly, 80% of the patients used 11 trays or less per year. Daily utilization differed between continuing and new patients. New patients had a bimodal use pattern. Over 30% were using > or = 1.75 vials/day and approximately 55% were using 0.25 to 1.25 vials/day. The majority of continuing patients (approximately 80%), however, used 0.25 to 1.25 vials/day. CONCLUSIONS: Most patients used about 1 vial per day, less than the labeled 2 per day. The cost to managed care for cyclosporine 0.05% ophthalmic emulsion may be less than anticipated. Key words: Cyclosporine 0.05% ophthalmic emulsion, longitudinal patient database, cost, utilization.|*Drug Utilization Review[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Cyclosporine/*administration & dosage[MESH]|Drug Prescriptions/*statistics & numerical data[MESH]|Dry Eye Syndromes/*drug therapy[MESH]|Female[MESH]|Humans[MESH]|Immunosuppressive Agents/*administration & dosage[MESH]|Male[MESH]|Managed Care Programs/statistics & numerical data[MESH]|Middle Aged[MESH]|Ophthalmic Solutions[MESH] |
