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lüll Nanosystems for simultaneous imaging and drug delivery to T cells Fahmy TM; Fong PM; Park J; Constable T; Saltzman WMAAPS J 2007[Jun]; 9 (2): E171-80The T-cell response defines the pathogenesis of many common chronic disease states, including diabetes, rheumatoid arthritis, and transplant rejection. Therefore, a diagnostic strategy that visualizes this response can potentially lead to early therapeutic intervention, avoiding catastrophic organ failure or prolonged sickness. In addition, the means to deliver a drug dose to those cells in situ with the same specificity used to image those cells would provide for a powerful therapeutic alternative for many disease states involving T cells. In this report, we review emerging nanosystems that can be used for simultaneous tracking and drug delivery to those cells. Because of their versatility, these systems--which combine specific receptor targeting with an imaging agent and drug delivery--are suited to both basic science and applications, from developing therapeutic strategies for autoimmune and alloimmune diseases, to noninvasive tracking of pathogenic T-cell migration.|*Contrast Media/administration & dosage[MESH]|*Drug Carriers/administration & dosage[MESH]|*Nanoparticles/administration & dosage[MESH]|*T-Lymphocytes/drug effects/immunology/metabolism[MESH]|Autoimmune Diseases/diagnosis/immunology[MESH]|Cell Movement/drug effects/immunology[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Pharmaceutical Preparations/*administration & dosage[MESH] |