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lüll Informatics challenges in structured RNA Laederach ABrief Bioinform 2007[Sep]; 8 (5): 294-303The world of regulatory RNAs is fast expanding into mainstream molecular biology as both a subject of intense mechanistic study and as a tool for functional characterization. The RNA world is one of complex structures that carry out catalysis, sense metabolites and synthesize proteins. The dynamic and structural nature of RNAs presents a whole new set of informatics challenges to the computational community. The ability to relate structure and dynamics to function will be key to understanding this complex world. I review several important classes of structured RNAs that present our community with a series of biologically novel informatics challenges. I also review available informatics tools that have been recently developed in the field.|*Models, Chemical[MESH]|*Models, Molecular[MESH]|*RNA Interference[MESH]|Computational Biology/*trends[MESH]|Nucleic Acid Conformation[MESH]|RNA/*chemistry/genetics/*ultrastructure[MESH]|Structure-Activity Relationship[MESH] |