Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues Chen Y; Jungsuwadee P; Vore M; Butterfield DA; St Clair DKMol Interv 2007[Jun]; 7 (3): 147-56Injury to nontargeted tissues in chemotherapy often complicates cancer treatment by limiting therapeutic dosages of anticancer drugs and by impairing the quality of life of patients during and after treatment. Oxidative stress, directly or indirectly caused by chemotherapeutics as exemplified by doxorubicin, is one of the underlying mechanisms of the toxicity of anticancer drugs in noncancerous tissues, including the heart and brain. A comprehensive understanding of the mechanisms of oxidative injury to normal tissue will be essential for the improvement of strategies to prevent or attenuate the toxicity of chemotherapeutic agents without compromising their chemotherapeutic value.|*Oxidative Stress/drug effects[MESH]|Animals[MESH]|Antineoplastic Agents/*adverse effects/chemistry/*therapeutic use[MESH]|Bystander Effect/*drug effects[MESH]|Humans[MESH]|Neoplasms/*drug therapy[MESH]|Reactive Nitrogen Species/metabolism[MESH]|Reactive Oxygen Species/metabolism[MESH] |