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  • Regulatory T cells in health and disease
  • Rouse BT
  • J Intern Med 2007[Jul]; 262 (1): 78-95
  • The healthy host does not normally develop tissue destructive autoimmunity in part because of the presence of natural regulatory T cells. These cells are best identified by their expression of a unique transcription factor forkhead box transcription factor (Foxp3) that controls their regulatory function. Several other types of regulatory T cells also occur most of which are induced in response to antigen stimulation. Some of these express the Foxp3 transcription factor but many do not. The role of natural T-regulatory cells as well as induceable regulatory cells in autoimmunity, cancer, allergy and infectious disease is described. The current status of therapeutic approaches that modulate regulatory T-cell responses on the outcome of experimental animal and human disease is also discussed.
  • |Animals[MESH]
  • |Autoimmune Diseases/*immunology/therapy[MESH]
  • |Autoimmunity[MESH]
  • |Disease Models, Animal[MESH]
  • |Forkhead Transcription Factors/analysis[MESH]
  • |Humans[MESH]
  • |Hypersensitivity, Immediate/immunology[MESH]
  • |Immune Tolerance/immunology[MESH]
  • |Infection/immunology[MESH]
  • |Neoplasms/immunology[MESH]
  • |T-Lymphocyte Subsets/immunology[MESH]
  • |T-Lymphocytes, Regulatory/*immunology[MESH]

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    *<b>[ Regulatory T cells in health and disease ]</b> J Intern Med 2007; 262(1) ; 78-95 Rouse BT


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    J Intern Med

    78 1.262 2007