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Regulatory T cells in health and disease Rouse BTJ Intern Med 2007[Jul]; 262 (1): 78-95The healthy host does not normally develop tissue destructive autoimmunity in part because of the presence of natural regulatory T cells. These cells are best identified by their expression of a unique transcription factor forkhead box transcription factor (Foxp3) that controls their regulatory function. Several other types of regulatory T cells also occur most of which are induced in response to antigen stimulation. Some of these express the Foxp3 transcription factor but many do not. The role of natural T-regulatory cells as well as induceable regulatory cells in autoimmunity, cancer, allergy and infectious disease is described. The current status of therapeutic approaches that modulate regulatory T-cell responses on the outcome of experimental animal and human disease is also discussed.|Animals[MESH]|Autoimmune Diseases/*immunology/therapy[MESH]|Autoimmunity[MESH]|Disease Models, Animal[MESH]|Forkhead Transcription Factors/analysis[MESH]|Humans[MESH]|Hypersensitivity, Immediate/immunology[MESH]|Immune Tolerance/immunology[MESH]|Infections/immunology[MESH]|Neoplasms/immunology[MESH]|T-Lymphocyte Subsets/immunology[MESH]|T-Lymphocytes, Regulatory/*immunology[MESH] |
