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Role of the vasodilator peptide angiotensin-(1-7) in cardiovascular drug therapy Schindler C; Bramlage P; Kirch W; Ferrario CMVasc Health Risk Manag 2007[]; 3 (1): 125-37The renin-angiotensin-system (RAS) is a cascade of enzymatic reactions resulting ultimately in the formation of angiotensin II. Recent research has expanded the knowledge about the RAS by adding new components to the pathways: angiotensin-(1-5) [Ang-1-5], angiotensin-(1-7) [Ang-(1-7)], angiotensin-(1-9) [Ang-(1-9)], an ACE homologous enzyme, ACE2, and the G-protein-coupled receptor mas as a molecular receptor for Ang-(1-7). Although previous studies provided some conflicting evidence about the relevance of Ang-(1-7) in the regulation of vascular and renal function, data now demonstrate that Ang-(1-7) contributes to the cardiovascular effects of ACE-inhibitors (ACE-1) and AT1-receptor-blockers (ARBs) both in experimental conditions and in humans. This review summarizes and critically discusses the currently available experimental and clinical study evidence for the role of Ang-(1-7) as a vasodilator and anti-trophic peptide in cardiovascular drug therapy. In addition, the potential therapeutic impact of currently available RAS blocking agents (ACE-1 and ARBs) and new agents still under development (renin-inhibitors) on the RAS-effector peptides is highlighted.|Angiotensin I/*therapeutic use[MESH]|Animals[MESH]|Antihypertensive Agents/*therapeutic use[MESH]|Cardiovascular Diseases/*drug therapy/metabolism/physiopathology[MESH]|Humans[MESH]|Peptide Fragments/*therapeutic use[MESH]|Renin-Angiotensin System/*drug effects[MESH]|Treatment Outcome[MESH]|Vasodilation/*drug effects/physiology[MESH] |
