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Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging Jackson A; O'Connor JP; Parker GJ; Jayson GCClin Cancer Res 2007[Jun]; 13 (12): 3449-59This article reviews the application of dynamic contrast-enhanced magnetic resonance imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis is placed on how variation in image acquisition and analysis affects the meaning and use of derived variables. We then review the potential for future developments, with particular reference to the application of dynamic contrast-enhanced magnetic resonance imaging to evaluate the heterogeneity of tumor tissues.|*Image Enhancement[MESH]|*Image Processing, Computer-Assisted[MESH]|*Magnetic Resonance Imaging[MESH]|*Neovascularization, Pathologic[MESH]|Angiogenesis Inhibitors/therapeutic use[MESH]|Animals[MESH]|Clinical Trials as Topic[MESH]|Humans[MESH]|Neoplasms/*blood supply/diagnostic imaging/drug therapy[MESH]|Radiography[MESH] |
