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Overview of tigecycline and its role in the era of antibiotic resistance Rossi F; Andreazzi DBraz J Infect Dis 2006[Jun]; 10 (3): 203-16The increasing antimicrobial resistance found in the many clinically important species of bacteria that commonly cause serious and life-threatening diseases presents a difficult challenge for clinicians, especially when an appropriate initial therapy must be chosen. New antibiotics are urgently needed to address the formidable issues associated with infections caused by vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae and multidrug-resistant Gram-negative bacteria. The need for new antibiotics that effectively resist antimicrobial mechanisms of resistance has become paramount. Tigecycline is a new antimicrobial agent; it is the first in a new class of antibiotics, the glycylcyclines, with properties conferring the ability to overcome many common resistance mechanisms, thus allowing the use of tigecycline for many serious and life-threatening infections for which the use of other antibiotics is no longer appropriate. Tigecycline is a novel expanded spectrum antibiotic that appears poised to meet the latest bacterial challenges facing clinicians, including the serious and life-threatening infections caused by highly resistant bacteria. Tigecycline, moreover, appears to hold promise as a new, versatile antibiotic that can be chosen for empirical therapy, even as a single agent, for initial therapy of many clinically important infections.|*Anti-Bacterial Agents/chemistry/therapeutic use[MESH]|Animals[MESH]|Bacterial Infections/*drug therapy/microbiology[MESH]|Disease Models, Animal[MESH]|Drug Resistance, Multiple, Bacterial[MESH]|Humans[MESH]|Microbial Sensitivity Tests[MESH]|Minocycline/*analogs & derivatives/chemistry/therapeutic use[MESH]|Tigecycline[MESH] |
