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lüll Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring Zhu Q; Tannenbaum S; Kurtzman SHSurg Oncol Clin N Am 2007[Apr]; 16 (2): 307-21Optical tomography with ultrasound (US) localization uses coregistered ultrasound images to guide optical imaging reconstruction. To simultaneously acquire US images and optical measurements, the authors used a hand-held probe consisting of a commercial US transducer and near-infrared optical imaging sensors of multiple wavelengths. A novel image scheme was used to map the ultrasound-visible lesions for optical imaging reconstruction. As a result, the problem of intense light scattering caused by breast tissue was overcome and reliable tumor hemoglobin concentration and blood oxygen saturation distributions from a group of patients were obtained. These functional parameters are valuable for aiding US diagnosis and for assessing chemotherapy response.|Breast Neoplasms/*diagnosis/therapy[MESH]|Clinical Trials as Topic[MESH]|Female[MESH]|Humans[MESH]|Image Processing, Computer-Assisted[MESH]|Tomography, Optical/instrumentation/*methods[MESH]|Ultrasonography, Mammary/instrumentation/*methods[MESH] |