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Assembly and trafficking of heterotrimeric G proteins Marrari Y; Crouthamel M; Irannejad R; Wedegaertner PBBiochemistry 2007[Jul]; 46 (26): 7665-77To be activated by cell surface G protein-coupled receptors, heterotrimeric G proteins must localize at the cytoplasmic surface of plasma membranes. Moreover, some G protein subunits are able to traffic reversibly from the plasma membrane to intracellular locations upon activation. This current topic will highlight new insights into how nascent G protein subunits are assembled and how they arrive at plasma membranes. In addition, recent reports have increased our knowledge of activation-induced trafficking of G proteins. Understanding G protein assembly and trafficking will lead to a greater understanding of novel ways that cells regulate G protein signaling.|Cell Membrane/*physiology[MESH]|Dimerization[MESH]|GTP-Binding Protein alpha Subunits/biosynthesis[MESH]|GTP-Binding Protein beta Subunits/biosynthesis[MESH]|GTP-Binding Protein gamma Subunits/biosynthesis[MESH]|Heterotrimeric GTP-Binding Proteins/*chemistry/*metabolism[MESH]|Models, Biological[MESH]|Protein Folding[MESH]|Protein Prenylation[MESH]|Protein Processing, Post-Translational[MESH]|Protein Transport/physiology[MESH]|Receptors, G-Protein-Coupled/physiology[MESH] |
