Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The macrophage at the crossroads of insulin resistance and atherosclerosis Liang CP; Han S; Senokuchi T; Tall ARCirc Res 2007[Jun]; 100 (11): 1546-55The macrophage has emerged as an important player in the pathogenesis of both atherosclerosis and insulin resistance. Cross-talk between inflammatory macrophages and adipocytes may be involved in insulin resistance in peripheral tissues. Defective insulin signaling in cells of the arterial wall including macrophages may promote the development of atherosclerosis. Insulin resistant macrophages are more susceptible to endoplasmic reticulum stress and apoptosis in response to various stimuli such as nutrient deprivation, free cholesterol loading, and oxidized LDL. Increased apoptosis of insulin resistant macrophages and impaired phagocytic clearance of apoptotic cells by insulin resistant macrophages in atherosclerotic lesions may lead to enhanced postapoptotic necrosis, larger lipid-rich cores, increased inflammation, and more complex vulnerable plaques.|*Insulin Resistance[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Apoptosis[MESH]|Atherosclerosis/*physiopathology[MESH]|Diabetes Mellitus/*physiopathology[MESH]|Disease Progression[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Humans[MESH]|Inflammation/physiopathology[MESH]|Macrophages/*metabolism[MESH]|Monocytes/metabolism[MESH] |