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lüll Myc goes global: new tricks for an old oncogene Knoepfler PSCancer Res 2007[Jun]; 67 (11): 5061-3Myc, a transcription factor commonly deregulated in tumorigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific target genes. However, it has been difficult to gain a precise understanding of how Myc drives cancer because Myc acts rather weakly at many of its target loci, and it has been reported to regulate as many as 10% to 15% of all cellular genes. A new perspective on this issue has been provided by a recent study that revealed Myc can regulate chromatin structure in a global fashion. These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator.|*Genes, myc[MESH]|Animals[MESH]|Humans[MESH]|Neoplasms/genetics/metabolism[MESH]|Proto-Oncogene Proteins c-myc/genetics/metabolism/*physiology[MESH] |