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The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy Abraham RT; Gibbons JJClin Cancer Res 2007[Jun]; 13 (11): 3109-14The immunosuppressive drug rapamycin played a key role in the functional characterization of mammalian target of rapamycin (mTOR), an unusual protein kinase that coordinates growth factor and nutrient availability with cell growth and proliferation. Several rapamycin-related compounds are now in various stages of clinical development as anticancer agents. This article highlights recent advances in our understanding of the mTOR signaling pathway and the implications of these findings for the clinical application of mTOR inhibitors in cancer patients.|*Gene Expression Regulation, Neoplastic[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacology[MESH]|Cell Enlargement[MESH]|Cell Proliferation[MESH]|Genes, Fungal[MESH]|Genotype[MESH]|Humans[MESH]|Models, Biological[MESH]|Neoplasms/metabolism/*therapy[MESH]|Phosphorylation[MESH]|Protein Kinases/*metabolism[MESH]|TOR Serine-Threonine Kinases[MESH] |
