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lüll Molecular characterization of post-thrombotic syndrome Phillips LJ 2nd; Sarkar RJ Vasc Surg 2007[Jun]; 45 Suppl A (ä): A116-22The post-thrombotic syndrome represents a poorly understood and significant vascular health problem. This review focuses on our current understanding of the pathogenesis of post-thrombotic syndrome. We emphasize the cellular and molecular mechanisms that are responsible for the critical components of post-thrombotic syndrome. These include the initiation of deep venous thrombosis, the pathogenesis of elevated venous pressure, and the factors responsible for nonhealing of venous stasis ulcers.|Chemokines/metabolism[MESH]|Extracellular Matrix Proteins/metabolism[MESH]|Fibrosis[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins/metabolism[MESH]|Matrix Metalloproteinases/metabolism[MESH]|Postphlebitic Syndrome/complications/etiology/*metabolism/pathology/physiopathology[MESH]|Risk Factors[MESH]|Varicose Ulcer/*etiology/metabolism/pathology/physiopathology[MESH]|Venous Pressure[MESH]|Venous Thrombosis/*complications/metabolism/pathology/physiopathology[MESH]|Wound Healing[MESH] |