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Pharmacogenetics of beta-blockers Shin J; Johnson JAPharmacotherapy 2007[Jun]; 27 (6): 874-87Beta-blockers are an important cardiovascular drug class, recommended as first-line treatment of numerous diseases such as heart failure, hypertension, and angina, as well as treatment after myocardial infarction. However, responses to a beta-blocker are variable among patients. Results of numerous studies now suggest that genetic polymorphisms may contribute to variability in responses to beta-blockers. This review summarizes the pharmacogenetic data for beta-blockers in patients with various diseases and discusses the potential implications of beta-blocker pharmacogenetics in clinical practice.|*Pharmacogenetics[MESH]|*Polymorphism, Genetic[MESH]|Adrenergic beta-Antagonists/*pharmacology/therapeutic use[MESH]|Blood Pressure/drug effects/genetics[MESH]|Cardiovascular Diseases/*drug therapy/genetics[MESH]|Cytochrome P-450 CYP2D6/genetics[MESH]|Heart Rate/drug effects/genetics[MESH]|Humans[MESH]|Receptors, Adrenergic, beta-1/genetics[MESH] |
