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lüll Primary effusion lymphoma Chen YB; Rahemtullah A; Hochberg EOncologist 2007[May]; 12 (5): 569-76Primary effusion lymphoma (PEL) is a rare HIV-associated non-Hodgkin's lymphoma (NHL) that accounts for approximately 4% of all HIV-associated NHL. PEL has a unique clinical presentation in having a predilection for arising in body cavities such as the pleural space, pericardium, and peritoneum. PEL cells are morphologically variable with a null lymphocyte immunophenotype and evidence of human herpesvirus (HHV)-8 infection. The exact oncogenic mechanisms of HHV-8 have not been clearly defined. Treatment is usually with combination CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy and antiretroviral therapy (if HIV positive). The prognosis for PEL is poor, with a median survival time of around 6 months. As the exact molecular steps in HHV-8-driven oncogenesis are unraveled, it is hoped that more specific therapeutic targets will be revealed.|Anti-Retroviral Agents/therapeutic use[MESH]|Antineoplastic Combined Chemotherapy Protocols/therapeutic use[MESH]|Ascitic Fluid/virology[MESH]|Cyclophosphamide/therapeutic use[MESH]|Doxorubicin/therapeutic use[MESH]|HIV Infections/complications/drug therapy[MESH]|Herpesviridae Infections/complications/drug therapy[MESH]|Herpesvirus 8, Human[MESH]|Humans[MESH]|Lymphoma, Non-Hodgkin/*diagnosis/drug therapy/pathology/virology[MESH]|Neoplasm Staging[MESH]|Pericardial Effusion/drug therapy/virology[MESH]|Pleural Effusion/drug therapy/virology[MESH]|Prednisone/therapeutic use[MESH]|Vincristine/therapeutic use[MESH] |