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Imaging-guided bone biopsy for osteomyelitis: are there factors associated with positive or negative cultures?Wu JS; Gorbachova T; Morrison WB; Haims AHAJR Am J Roentgenol 2007[Jun]; 188 (6): 1529-34OBJECTIVE: The objective of our study was to identify the clinical and technical factors associated with positive or negative culture results in histologically positive cases of osteomyelitis obtained from imaging-guided bone biopsies. MATERIALS AND METHODS: A retrospective review was performed of 800 consecutive patients undergoing imaging-guided core bone biopsies at two institutions. Seventy-five biopsies were performed for suspected osteomyelitis and 41 patients had histologically proven osteomyelitis. A chart review was performed to determine whether the following factors affected the culture result: histologic type of osteomyelitis, antibiotic therapy before biopsy, fever (temperature > or = 38.0 degrees C), elevated WBC count (> or = 10 x 10(3) microL), elevated erythrocyte sedimentation rate (ESR) (> or = 10 mm/h), elevated C-reactive protein value (CRP) (> or = 6 mg/L), the size of the biopsy needle, and the amount of purulent fluid obtained at biopsy. RESULTS: Of the 41 cases of osteomyelitis, 14 (34%) had positive cultures. Eighteen (44%) of 41 cases were chronic osteomyelitis. Seventeen (41%) of 41 patients received antibiotics before biopsy, seven (17%) were febrile, five (12%) had an elevated WBC count, 16 (39%) had an elevated ESR, and six (15%) had an elevated CRP value. The biopsy needle size ranged from 11- to 18-gauge. These factors did not have any significant association with positive or negative culture results. Purulent fluid was aspirated in 10 (24%) of the 41 cases. In six (15%) of the cases, > or = 2 mL of purulent fluid was aspirated and five (83%) of the six cases were associated with positive culture (p = 0.02). CONCLUSION: The rate of positive culture results in histologically proven cases of osteomyelitis obtained from imaging-guided bone biopsies is low. Aspirating > or = 2 mL of purulent fluid is associated with a significantly higher rate of positive cultures.|*Artifacts[MESH]|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Biopsy, Needle/*statistics & numerical data[MESH]|Bone and Bones/diagnostic imaging/*pathology[MESH]|Child[MESH]|Child, Preschool[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Massachusetts/epidemiology[MESH]|Middle Aged[MESH]|Osteomyelitis/diagnostic imaging/*epidemiology/*pathology[MESH]|Pennsylvania/epidemiology[MESH]|Radiography[MESH]|Reproducibility of Results[MESH]|Sensitivity and Specificity[MESH]|Specimen Handling/methods/statistics & numerical data[MESH]|Surgery, Computer-Assisted/statistics & numerical data[MESH] |
