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lüll PCNA, the maestro of the replication fork Moldovan GL; Pfander B; Jentsch SCell 2007[May]; 129 (4): 665-79Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial players to the replication fork. Remarkably, many factors that are involved in replication-linked processes interact with a particular face of PCNA and through the same interaction domain, indicating that these interactions do not occur simultaneously during replication. Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO.|Animals[MESH]|Cell Cycle Proteins/genetics[MESH]|DNA Repair/genetics[MESH]|DNA Replication/*genetics[MESH]|DNA-Binding Proteins/genetics[MESH]|DNA-Directed DNA Polymerase/genetics/metabolism[MESH]|Epigenesis, Genetic/genetics[MESH]|Genomic Instability/*genetics[MESH]|Humans[MESH]|Proliferating Cell Nuclear Antigen/*genetics[MESH]|S Phase/*genetics[MESH] |