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lüll NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotype Hasserjian RP; Harris NLAm J Clin Pathol 2007[Jun]; 127 (6): 860-8Natural killer (NK) cells are lymphocytes that have some phenotypic and functional similarities to cytotoxic T cells but do not express the T-cell receptor complex. NK-cell malignancies may be localized or disseminated at initial examination, and most behave aggressively. The variable presentation of NK-cell lymphomas and leukemias suggests that they represent a spectrum of disease, with Epstein-Barr virus (EBV) implicated in the pathogenesis of most cases. Using cases presented in Session 10 of the 2005 Society for Hematopathology/European Association for Haematopathology Workshop on T-cell and NK-cell malignancies, we discuss outstanding issues in the classification and diagnosis of NK-cell malignancies. These difficulties are related to unusual sites of manifestation, atypical immunophenotypic features, and EBV+ T-cell tumors that resemble classical extranodal NK/T-cell lymphoma, nasal-type (EN-NK/T-NT). Although some of these cases can be grouped into ENNK/T-NT, classification of tumors that have atypical or discordant features will remain controversial, particularly when EBV is absent.|Epstein-Barr Virus Infections/complications/immunology/pathology[MESH]|Herpesvirus 4, Human/genetics/isolation & purification/pathogenicity[MESH]|Humans[MESH]|Immunophenotyping[MESH]|Killer Cells, Natural/*pathology[MESH]|Leukemia/immunology/*pathology/virology[MESH]|Lymphoma, Non-Hodgkin/immunology/*pathology/virology[MESH]|RNA, Viral/isolation & purification[MESH]|T-Lymphocytes/*pathology[MESH] |