Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Pivotal advance: endogenous pathway to SIRS, sepsis, and related conditions Tang AH; Brunn GJ; Cascalho M; Platt JLJ Leukoc Biol 2007[Aug]; 82 (2): 282-5TLRs are usually thought to recognize substances produced by microorganisms and thus, to initiate host defenses. This concept, however, fails to explain some functions of this family of receptors. Recognition of endogenous substances may explain the broader functions of TLRs in physiology and disease. Activation of TLRs by endogenous substances necessitates vigorous control of the function of the receptors. This communication will summarize a line of research, which points to an endogenous agonist for TLR4 and a putative mechanism for controlling the function of that receptor.|Animals[MESH]|Heparitin Sulfate/immunology/metabolism[MESH]|Humans[MESH]|Sepsis/*immunology/pathology[MESH]|Systemic Inflammatory Response Syndrome/*immunology/pathology[MESH]|Toll-Like Receptors/agonists/genetics/immunology/metabolism[MESH] |
